Tag: disease

I Hope This Is True – Diabetes Cure

Don’t bother reading the boxed text unless you’re a physician. Even then you might skip it. It’s from the journal “Cell.”

In type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1+ pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and β cell stress of prediabetic NOD mice are prevented when TRPV1+ neurons are eliminated. TRPV1NOD, localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1−/− mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1+ sensory neurons in β cell function and diabetes pathoetiology.

What that exercise in ‘academic speak’ says is, Canadian scientists might have found a cure for diabetes. If true, this is amazing news.

In a more human friendly article from Canada’s National Post:

In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body’s nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians.

Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas.

Operative words: “healthy overnight.” For families of diabetics, that little phrase is the answer to years of prayers.

You probably know I’m involved in the Juvenile Diabetes Research Foundation. I am touched by the stories of the families affected by diabetes. It’s no less tragic when it’s Type 2, or adult onset diabetes.

Children with diabetes have a life span more than ten years shorter than non-diabetic kids. And then there’s the daily trouble and worries that come with being diabetic.

Each year I say, “I hope this is my last JDRF Walk.” Maybe I’ve already walked it!

I sent the article and a brief note to Mary Kessler, who runs the local JDRF chapter.

We are all very excited-thanks for sending it on to me.

Try not to get too excited about it yet, we have had these miracles before and they did not translate to humans-but I am keeping my fingers crossed.

She’s right. Some exciting progress, using stem cell research, fizzled only a few months ago. What looked very good at the outset was just an empty promise.

Still, if there’s going to be a cure, it’s likely to start with an announcement like this one. My fingers are crossed.

Party for Dr. Mel

About 7 years ago, one of the people I work with in the Weather Department discovered he had cancer. Dr. Mel Goldstein, known by everyone as Dr. Mel, had multiple myeloma, a cancer of the plasma cells. Mel had discovered his disease after back pain from a car accident just wouldn’t go away.

Today, Mel and his wife Arlene threw a party. They have a home right on Long Island Sound just east of New Haven. The weather was perfect, making their view of the Sound even better. Long Island was clearly visible on the horizon.

I remember going to Mel’s home right after he found out what he had. I was with Jeff Bailey, our webguy at the station. We went to install a PC at Mel’s house so he could track the weather from home. We hooked up the computer and a modem and then proceeded to show him how to search using Google. This was a while ago and not nearly as many people were web savvy.

We reached the site of the Multiple Myeloma Society. It was a good first example, because Mel and his wife were desperate for information. We all read along silently, not realizing that the page contained a reference to the average time from discovery to mortality – how long someone normally lived after finding out he had multiple myeloma.

I don’t remember the number, except it was was under 1,000 days.

Obviously, Dr. Mel has outlived those projections. This is not to say the disease hasn’t taken a toll, because it has. Not only has he lived with the specter of death, but also the physical pain caused by the cancer’s effect on his bones.

He has lost 6-7″ in height and walks with a cane. At the station, we’ve installed a ramp to allow him to reach the studio floor easily. At home, a small motorized chair saves him from walking the stairs to the second floor. I know he is in pain each and every day.

Today’s party was to celebrate another milestone in living beyond anyone’s expectations. But this is not a story of luck. He is alive because of his own persistence. Dr. Mel became his own best advocate for care. Though not a medical doctor, he became an expert on multiple myeloma and was able to help his physicians guide his own treatment.

Without dedication, Mel would be dead. If he had given up, gone through the motions with his cancer treatment, he would be dead. But he chose not to die. He chose to aggressively fight.

There is no cure for multiple myeloma right now. There is therapy which is working. How long this fire hose treatment will keep the flames down is anyone’s guess.

Meanwhile, today was worth celebrating.